Success and Failure in Human Spermatogenesis as Revealed by Teratozoospermic RNAs Running head: A Sperm’s RNA Diagnostic Tail

Adrian E. Platts, David J. Dix, Hector E. Chemes, Kary E. Thompson, Robert Goodrich, John C. Rockett, Vanesa Y. Rawe, Silvina Quintana, Michael P. Diamond, Lillian F. Strader and Stephen A. Krawetz* Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Office of Research and Development, U.S. Environmental Protection Agency, USA, Centro de Investigaciones Endocrinologicas, Argentina Centro de Estudios en Ginecología y Reproducción, Argentina,Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Institue for Scientific Computing, Wayne State University. Submitted to: Human Molecular Genetics HMG-2006D-01086 December, 29, 2006 And in revised form: January 26, 2007 Correspondence to: *Stephen A. Krawetz Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, 253 C.S. Mott Center; 275 East Hancock; Detroit, MI, USA 48201 Laboratory phone: 313-577-0765; Office phone: 313-577-6770; FAX: 313-577-8554 Email: [email protected]